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Symbol Name ID |
Ptpn22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid) MGI:107170 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Leukopenia |
Hemophagocytosis |
Chronic lymphatic leukemia |
Stomatitis |
Recurrent pharyngitis |
Keratoconjunctivitis sicca |
Pericarditis |
Lymphadenopathy |
Mediastinal lymphadenopathy |
Thymoma |
Hepatosplenomegaly |
Gastrointestinal inflammation |
Recurrent gastroenteritis |
Acute hepatitis |
Chronic hepatitis |
Iridocyclitis |
Inflammatory abnormality of the eye |
Epididymitis |
Lupus nephritis |
Nephritis |
Abnormality of the immune system |
Fasciitis |
Inflammatory abnormality of the skin |
Erythema nodosum |
Discoid lupus rash |
Maculopapular exanthema |
Malar rash |
Myositis |
Pneumonia |
Serositis |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Autoimmunity |
Anti-citrullinated protein antibody positivity |
Antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Platelet antibody positive |
Rheumatoid factor positive |
Systemic lupus erythematosus |
Cellular immunodeficiency |
Recurrent infections |
Meningitis |
| Disease(s) Associated with PTPN22 | ||||||||||||||||||||||||||||||||||||||||||||||||
| alopecia areata | ||||||||||||||||||||||||||||||||||||||||||||||||
| autoimmune thrombocytopenic purpura | ||||||||||||||||||||||||||||||||||||||||||||||||
| Behcet's disease | ||||||||||||||||||||||||||||||||||||||||||||||||
| chronic lymphocytic leukemia | ||||||||||||||||||||||||||||||||||||||||||||||||
| graft-versus-host disease | ||||||||||||||||||||||||||||||||||||||||||||||||
| myasthenia gravis | ||||||||||||||||||||||||||||||||||||||||||||||||
| rheumatoid arthritis | ||||||||||||||||||||||||||||||||||||||||||||||||
| Sjogren's syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||
| systemic lupus erythematosus | ||||||||||||||||||||||||||||||||||||||||||||||||
| temporal arteritis | ||||||||||||||||||||||||||||||||||||||||||||||||
| type 1 diabetes mellitus |
| Mouse Phenotypes | immune system phenotype |
decreased B cell apoptosis |
increased B cell proliferation |
increased T cell proliferation |
abnormal thymus morphology |
enlarged thymus |
thymus hyperplasia |
abnormal thymocyte activation |
enlarged spleen |
spleen hyperplasia |
abnormal B cell differentiation |
increased transitional stage T1 B cell number |
abnormal T cell differentiation |
abnormal double-positive T cell morphology |
increased double-positive T cell number |
increased dendritic cell number |
abnormal B cell number |
increased germinal center B cell number |
decreased mature B cell number |
decreased follicular B cell number |
increased follicular B cell number |
increased B cell number |
abnormal T cell subpopulation ratio |
abnormal T cell number |
increased effector memory CD4-positive, alpha-beta T cell number |
increased CD4-positive, alpha-beta memory T cell number |
increased CD4-positive, alpha-beta T cell number |
increased effector memory CD8-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
increased memory T cell number |
increased regulatory T cell number |
increased T cell number |
abnormal B cell morphology |
abnormal T cell morphology |
increased spleen germinal center number |
increased spleen germinal center size |
abnormal B cell physiology |
abnormal B cell activation |
increased IgE level |
increased IgG1 level |
increased IgG2a level |
increased IgG3 level |
increased IgM level |
abnormal T cell physiology |
abnormal T cell activation |
abnormal Peyer's patch germinal center morphology |
enlarged lymph nodes |
abnormal dendritic cell physiology |
increased interleukin-12 secretion |
increased interleukin-2 secretion |
autoimmune response |
increased autoantibody level |
increased anti-insulin autoantibody level |
increased anti-double stranded DNA antibody level |
increased inflammatory response |
glomerulonephritis |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ptpn22tm1.1Draw/Ptpn22tm1.1Draw | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ptpn22tm1.1Kas/Ptpn22tm1.1Kas | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ptpn22tm1Achn/Ptpn22tm1Achn | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ptpn22tm2Achn/Ptpn22tm2Achn | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ptpn22tm1.1Draw/Ptpn22+ | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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